The media attention and subsequent scientific backlash engendered by the claim, announced by spokespeople for the Encyclopedia of DNA Elements project, that 80% of the human genome has a “biochemical function” highlights the need for a clearer understanding of function concepts in biology. This article provides an overview of two major function concepts that have been developed in the philosophy of science – the “causal role” concept and the “selected effects” concept – and their relevance to ENCODE. Unlike some previous (...) critiques, the ENCODE project is not considered problematic because it employed a causal role definition of function, but because of how this concept was misused. In addition, several unique challenges that arise when dealing with transposable elements, but which were ignored by ENCODE, are highlighted. These include issues surrounding TE-level versus organism-level selection, the origins versus the persistence of elements, and accidental versus functional organism-level benefits. Finally, some key questions are presented that should be addressed in any studies aiming to ascribe functions to major portions of large eukaryotic genomes, the majority of which is made up of transposable elements. (shrink)

Considerable variation exists not only in the kinds of transposable elements (TEs) occurring within the genomes of different species, but also in their abundance and distribution. Noting a similarity to the assortment of organisms among ecosystems, some researchers have called for an ecological approach to the study of transposon dynamics. However, there are several ways to adopt such an approach, and it is sometimes unclear what an ecological perspective will add to the existing co-evolutionary framework for explaining transposon-host interactions. This (...) review aims to clarify the conceptual foundations of transposon ecology in order to evaluate its explanatory prospects. We begin by identifying three unanswered questions regarding the abundance and distribution of TEs that potentially call for an ecological explanation. We then offer an operational distinction between evolutionary and ecological approaches to these questions. By determining the amount of variance in transposon abundance and distribution that is explained by ecological and evolutionary factors, respectively, it is possible empirically to assess the prospects for each of these explanatory frameworks. To illustrate how this methodology applies to a concrete example, we analyzed whole-genome data for one set of distantly related mammals and another more closely related group of arthropods. Our expectation was that ecological factors are most informative for explaining differences among individual TE lineages, rather than TE families, and for explaining their distribution among closely related as opposed to distantly related host genomes. We found that, in these data sets, ecological factors do in fact explain most of the variation in TE abundance and distribution among TE lineages across less distantly related host organisms. Evolutionary factors were not significant at these levels. However, the explanatory roles of evolution and ecology become inverted at the level of TE families or among more distantly related genomes. Not only does this example demonstrate the utility of our distinction between ecological and evolutionary perspectives, it further suggests an appropriate explanatory domain for the burgeoning discipline of transposon ecology. The fact that ecological processes appear to be impacting TE lineages over relatively short time scales further raises the possibility that transposons might serve as useful model systems for testing more general hypotheses in ecology. (shrink)

A promising recent development in molecular biology involves viewing the genome as a miniecosystem, where genetic elements are compared to organisms and the surrounding cellular and genomic structures are regarded as the local environment. Here we critically evaluate the prospects of Ecological Neutral Theory, a popular model in ecology, as it applies at the genomic level. This assessment requires an overview of the controversy surrounding neutral models in community ecology. In particular, we discuss the limitations of using ENT both as (...) an explanation of community dynamics and as a null hypothesis. We then analyze a case study in which ENT has been applied to genomic data. Our central finding is that genetic elements do not conform to the requirements of ENT once its assumptions and limitations are made explicit. We further compare this genome-level application of ENT to two other, more familiar approaches in genomics that rely on neutral mechanisms: Kimura’s Molecular Neutral Theory and Lynch’s Mutational Hazard Model. Interestingly, this comparison reveals that there are two distinct concepts of neutrality associated with these models which we dub ‘fitness-neutrality’ and ‘competitive neutrality’. This distinction helps to clarify the various roles for neutral models in genomics, for example, in explaining the evolution of genome size. (shrink)

Since the late 1980s, in defiance of Sri Lanka’s major monastic fraternities and the government, Buddhist women and men have begun to organize across distinctions of national boundary and Buddhist tradition to reinstate a defunct bhikkhun? ordination lineage for renunciant women. Drawing on fieldwork from the winter of 2015–16, this article considers some of the strategies by which Sri Lanka’s bhikkhun?s and their supporters constitute the burgeoning lineage as both legitimate and necessary for the continued health and vitality of an (...) otherwise ailing Buddhist s?sana. I argue that Sri Lanka’s bhikkhun?s engage in highly-visible forms of adherence to vinaya rules and social expectations for ideal monastic behavior set against a popular discourse about the laxity of male renunciants. Such engagement is both political and soteriological; while it is aimed at fulfilling legitimizing gendered expectations of women’s piety, it is expressed primarily in terms of the eradication of personal and societal suffering through forms of practice that accord with the ideal of a pious monastic. Thus, in contrast to discourses which locate bhikkhun?s as subjects whose presence weakens the s?sana’s duration and strength, in this new discourse Sri Lanka’s bhikkhun?s become virtuous agents of social service and moral restoration. The article concludes by identifying emerging connections between this discourse and an alreadygendered xenophobic Buddhist nationalism. (shrink)

Living related organ transplantation is morally problematic for two reasons. First, it requires surgeons to perform nontherapeutic, even dangerous procedures on healthy donors—and in the case of children, without their consent. Second, the transplant donor and recipient are often intimately related to each other, as parent and child, or as siblings. These relationships challenge our conventional models of medical decisionmaking. Is there anything morally problematic about a parent allowing the interests of one child to be risked for the sake of (...) another? What exactly are the interests of the prospective child donor whose sibling will die without an organ? Is the choice of a parent to take risks for the sake of her child truly free, or is the specter of coercion necessarily raised? (shrink)

The discovery and ongoing investigation of microRNAs suggest important conceptual and methodological lessons for philosophers and historians of biology. This paper provides an account of miRNA research and the shift from viewing these tiny regulatory entities as minor curiosities to seeing them as major players in the post-transcriptional regulation of genes. Conceptually, the study of miRNAs is part of a broader change in understandings of genetic regulation, in which simple switch-like mechanisms were reinterpreted as aspects of complex cellular and genome-wide (...) processes. Among them are the activities of small RNAs, previously regarded as non-functional. Methodologically, the miRNA story suggests new ways of characterizing biological research that should prove helpful to philosophers of science who seek to develop more pluralistic, pragmatic models of scientific inquiry. miRNA research displays iterative movements between multiple modes of investigation that include not only the proposal and testing of hypotheses but also exploratory, technology-oriented and question-driven modes of research. As an exemplary story of scientific discovery and development, the miRNA case illustrates transitions from genetics to genomics and systems biology, and it shows how diverse configurations of research practice are related to major scientific advances. (shrink)

Presymptomatic testing for Huntington's disease has given rise to several ethical problems relating to such issues as confidentiality, the privacy of the individual, the testing of minors and informed consent in connection with blood sample donation. A multidisciplinary conference of staff from genetic centres involved with presymptomatic testing was organised in Cardiff to discuss these and other problems. Recommendations on good practice are described under four headings: pre- and post-test counselling; confidentiality in relation to test results; collection and storage of (...) DNA, and criteria for testing. (shrink)

Computability theory is used to evaluate the complexity of classifying various kinds of Lebesgue spaces and associated isometric isomorphism problems.

Mainstream economics evaluates capitalism primarily from the perspective of efficiency. Social philosophy typically applies other or additional normative criteria, such as equality, democracy, and community. This essay examines the implications of these contrasting sets of criteria in the evaluation of capitalism. Its first two sections consider the criteria themselves, assuming that a trade-off exists between them. The last three sections question whether such a trade-off necessarily occurs, and explore the claim that improvements in nonefficiency dimensions of capitalist society may enhance, (...) rather than conflict with, efficiency. (shrink)

This Element introduces the philosophical literature on values in science by examining four questions: How do values influence science? Should we actively incorporate values in science? How can we manage values in science responsibly? What are some next steps for those who want to help promote responsible roles for values in science? It explores arguments for and against the “value-free ideal” for science and concludes that it should be rejected. Nonetheless, this does not mean that value influences are always acceptable. (...) The Element explores a range of strategies for distinguishing between appropriate and inappropriate value influences. It concludes by proposing an approach for managing values in science that relies on justifying, prioritising, and implementing norms for scientific research practices and institutions. (shrink)

We argue that the analysis of cognitive attitudes should play a central role in developing more sophisticated accounts of the proper roles for values in science. First, we show that the major recent efforts to delineate appropriate roles for values in science would be strengthened by making clearer distinctions among cognitive attitudes. Next, we turn to a specific example and argue that a more careful account of the distinction between the attitudes of belief and acceptance can contribute to a better (...) understanding of the proper roles for values in a case study from paleoanthropology. (shrink)

There has been relatively little effort to provide a systematic overview of different forms of exploratory experimentation (EE). The present paper examines the growing subdiscipline of nanotoxicology and suggests that it illustrates at least four ways that researchers can engage in EE: searching for regularities; developing new techniques, simulation models, and instrumentation; collecting and analyzing large swaths of data using new experimental strategies (e.g., computer-based simulation and "high-throughput" instrumentation); and structuring an entire disciplinary field around exploratory research agendas. In order (...) to distinguish these and other activities more effectively, the paper proposes a taxonomy that includes three dimensions along which types of EE vary: (1) the aim of the experimental activity, (2) the role of theory in the activity, and (3) the methods or strategies employed for varying experimental parameters. (shrink)

Many people feel uneasy about enhancement technologies, yet have a hard time explaining why. This unease is often less with the technologies themselves than about the desires and aspirations that they express. I suggest here that we can diagnose the source of that unease by looking at three themes that emerge in Taylor’s writings about the making of the modern self: the importance of social recognition, the ethics of authenticity, and the rise of instrumental reason.

Scholars working in science and technology studies have recently argued that we could learn much about the nature of scientific knowledge by paying closer attention to scientific ignorance. Building on the work of Robert Proctor, this article shows how ignorance can stem from a wide range of selective research choices that incline researchers toward partial, limited understandings of complex phenomena. A recent report produced by the International Assessment of Agricultural Knowledge, Science, and Technology for Development serves as the article’s central (...) case study. After arguing that the forms of selective ignorance illustrated in cases like this one are both socially important and difficult to address, I suggest several strategies for responding to them in a socially responsible manner. (shrink)

Not all probability ascriptions that appear in scientific theories describe chances. There is a question about whether probability ascriptions in non-fundamental sciences, such as those found in evolutionary biology and statistical mechanics, describe chances in deterministic worlds and about whether there could be any chances in deterministic worlds. Recent debate over whether chance is compatible with determinism has unearthed two strategies for arguing about whether a probability ascription describes chance—that is, to speak metaphorically, two different strategies for figuring out where (...) the chances are: find the chances by focusing on chance’s explanatory role or find the chances by focusing on chance’s predictive role. These two strategies tend to yield conflicting results about where the chances are, and debate over which strategy is appropriate tends to end in stalemate. After discussing these two strategies, I consider a new view of chance’s explanatory role. I argue that one theoretical advantage of this new view is that allows us to make progress on the question of where the chances are by providing a principled way of determining which probability ascriptions describe chances. From the vantage of this new view, the correct application of both strategies involves figuring out where the chances are by figuring out where the probabilistic scientific explanations are and what those explanations are like. (shrink)

The potential for financial conflicts of interest (COIs) to damage the credibility of scientific research has become a significant social concern, especially in the wake of high-profile incidents involving the pharmaceutical, tobacco, fossil-fuel, and chemical industries. Scientists and policy makers have debated whether the presence of financial COIs should count as a reason for treating research with suspicion or whether research should instead be evaluated solely based on its scientific quality. This paper examines a recent proposal to develop criteria for (...) evaluating the credibility of research without considering its source of funding. It concludes that proposals of this sort are likely to be either ineffective or impractical in many cases. Nevertheless, this does not imply that all research funded by those with an interest in the outcome must be placed under a cloud of suspicion; there are conditions under which research is at much more serious risk of being corrupted than in other cases, and attention to these conditions can guide productive responses to financial COIs. (shrink)

ABSTRACT According to comparativism, comparative confidence is more fundamental than absolute confidence. In two recent AJP papers, Stefánsson has argued that comparativism is capable of explaining interpersonal confidence comparisons. In this paper, I will argue that Stefansson’s proposed explanation is inadequate; that we have good reasons to think that comparativism cannot handle interpersonal comparisons; and that the best explanation of interpersonal comparisons requires thinking about confidence in a fundamentally different way than that which comparativists propose: specifically, we should think of (...) confidence as a dimensionless quantity. (shrink)

Reporters and editors share values. If there were no shared values essential to the practice of journalism, it would be impossible to distinguish a journalist from other mass communicators. The set of journalistic values provides the base for an argument that journalists are pluralists, not relativists.

Prediction is an important aspect of scientific practice, because it helps us to confirm theories and effectively intervene on the systems we are investigating. In ecology, prediction is a controversial topic: even though the number of papers focusing on prediction is constantly increasing, many ecologists believe that the quality of ecological predictions is unacceptably low, in the sense that they are not sufficiently accurate sufficiently often. Moreover, ecologists disagree on how predictions can be improved. On one side are the ‘theory-driven’ (...) ecologists, those who believe that ecology lacks a sufficiently strong theoretical framework. For them, more general theories will yield more accurate predictions. On the other are the ‘applied’ ecologists, whose research is focused on effective interventions on ecological systems. For them, deeper knowledge of the system in question is more important than background theory. The aim of this paper is to provide a philosophical examination of both sides of the debate: as there are strengths and weaknesses in both approaches to prediction, a pluralistic approach is best for the future of predictive ecology. (shrink)

Possible worlds models of belief have difficulties accounting for unawareness, the inability to entertain (and hence believe) certain propositions. Accommodating unawareness is important for adequately modelling epistemic states, and representing the informational content to which agents have in principle access given their explicit beliefs. In this paper, I develop a model of explicit belief, awareness, and informational content, along with an sound and complete axiomatisation. I furthermore defend the model against the seminal impossibility result of Dekel, Lipman and Rustichini, according (...) to which three intuitive conditions preclude non-trivial unawareness on any possible worlds model of belief. (shrink)

This volume offers a critical appreciation of the work of 16 leading curriculum theorists through critical expositions of their writings. Written by a leading name in Curriculum Studies, the book includes a balance of established curriculum thinkers and contemporary curriculum analysts from education as well as philosophy, sociology and psychology. With theorists from the UK, the US and Europe, there is also a spread of political perspectives from radical conservatism through liberalism to socialism and libertarianism. Theorists included are: John Dewey, (...) Lev Vygotsky, Ralph Tyler, Joseph Schwab, Jerome Bruner, Maxine Greene, Basil Bernstein, Micheal Foucault, Paul Hirst, Donald Schon, Lawrence Stenhouse, Elliott Eisner, John White, Michael Apple, Henry Giroux and Robin Usher. This book is ideal for students looking for an introduction to some of the key educational thinkers of our time. It can also be used as a companion volume to the Routledge four-volume set on Curriculum Theory , 2003, which is also edited by David Scott. (shrink)

Ethicists widely accept the notion that scientists have moral responsibilities to benefit society at large. The dissemination of scientific information to the public and its political representatives is central to many of the ways in which scientists serve society. Unfortunately, the task of providing information can often give rise to moral quandaries when scientific experts participate in politically charged debates over issues that are fraught with uncertainty. This paper develops a theoretical framework for an “ethics of expertise” (EOE) based on (...) the notion that scientists have responsibilities to provide information in a way that promotes autonomous decision-making on the part of the public and its representatives. Moreover, insofar as the principle of informed consent has developed in biomedical ethics as a way for physicians to promote autonomous decision-making on the part of their patients, this paper suggests that the informed-consent concept may suggest a set of criteria and guidelines that can help scientists to fulfill their similar ethical responsibilities to the public. In order to illustrate how the resulting EOE could provide practical guidance for scientific experts, the paper examines a case study involving the dissemination of information about the low-dose biological effects of toxic chemicals and carcinogens. (shrink)

The diagnosis of psychopathy is controversial largely because of two notions: first, that because of their defects, psychopaths cannot understand morality, and second, that these defects should thus excuse psychopaths from moral responsibility for their actions. However, it is not clear just what is involved in understanding morality. The argument that the psychopath is ignorant of morality in the same way that one might be ignorant of facts is difficult to sustain. However, a closer examination of the psychopath's peculiar deficiencies (...) reveals that the psychopath's understanding of morality might be impaired in other ways. Keywords: disease, ethics, philosophy, psychopathy, psychiatry, responsibility. (shrink)

This paper argues, first, that recent studies of experimentation, most notably by Deborah Mayo, provide the conceptual resources to describe scientific discovery's early stages as error-probing processes. Second, it shows that this description yields greater understanding of those early stages, including the challenges that they pose, the research strategies associated with them, and their influence on the rest of the discovery process. Throughout, the paper examines the phenomenon of "chemical hormesis" (i.e., anomalous low-dose effects from toxic chemicals) as a case (...) study that is important not only for the biological sciences but also for contemporary public policy. The resulting analysis is significant for at least two reasons. First, by elucidating the importance of discovery's earliest stages, it expands previous accounts by philosophers such as William Wimsatt and Lindley Darden. Second, it identifies the discovery process as yet another philosophical topic on which the detailed studies of the "new experimentalists" can shed new light. (shrink)

Over the last two decades the work of Jean-Luc Nancy and Giorgio Agamben has attracted widespread attention both within philosophy and more broadly across the human sciences. Central to the thinking of Nancy and Agamben is a shared theory of community that offers a model of resistance to oppressive power through radical passivity. This article argues that this model inherits the inadequacies of Martin Heidegger’s attempts to conceptualize society and history. More specifically, Heidegger’s understanding of collective history in terms of (...) ‘destiny’ implicitly regulates the figure of community proposed by Nancy and Agamben. This alignment with the Heideggerian notion of destiny means that these later thinkers fail to offer a credible model of resistance in terms of concretely determined means of productive counter-practices. As a consequence the usefulness of the thinking of Nancy and Agamben as a conceptual framework for emancipatory politics is at best extremely limited. (shrink)

The traditional philosophy of science approach to prediction leaves little room for appreciating the value and potential of imprecise predictions. At best, they are considered a stepping stone to more precise predictions, while at worst they are viewed as detracting from the scientific quality of a discipline. The aim of this paper is to show that imprecise predictions are undervalued in philosophy of science. I review the conceptions of imprecise predictions and the main criticisms levelled against them: (i) that they (...) cannot aid in model selection and improvement, and (ii) that they cannot support effective interventions in practical decision making. I will argue against both criticisms, showing that imprecise predictions have a circumscribed but important and legitimate place in the study of complex, heterogeneous systems. The argument is illustrated and supported by an example from conservation biology, where imprecise models were instrumental in saving the kōkako from extinction. (shrink)

“Thinking from the perspective of women’s lives makes strange what had appeared familiar, which is the beginning of any scientific inquiry.” Seeing as strange what had appeared familiar is the beginning of any inquiry, I think. I do not question my drinking water until it smells of chlorine. I do not ask why I was given the correct amount of change; I do not ask why I am treated with respect. In philosophical inquiry, I do not ask “What is a (...) cat?” but “What is Being?” Similarly, in the political realm, one does not question a social order which works well. Here the question arises, “Works well for whom?” Well, for those who aren’t troubled by it, those who do not question it, those for whom it does not seem strange. (shrink)

Relatively few thinkers have attempted to develop a systematic ‘ethics of expertise’ (EOE) that can guide scientists and other technical experts in providing information to the public. This paper argues that the prima facie duty to disseminate information in a manner that does not damage the self-determination of decision makers could fruitfully serve as one of the core principles of an EOE. Moreover, this duty can be fleshed out in promising ways by drawing on the concept of informed consent, which (...) guides medical clinicians in preserving the self-determination of their patients. The paper applies the resulting ethical framework to recent policy discussions about hydrogen fuel-cell (HFC) vehicles, both because they have received a good deal of research funding and because their merits have been hotly debated. It concludes that technical experts providing information about HFC vehicles should be especially cognizant of three issues: (1) important alternatives to hydrogen technology that need to be addressed, (2) major false beliefs that should be prevented or corrected, and (3) significant framing effects that could influence the recipients of information. (shrink)

: This paper examines the epistemological warrant for a toxicological phenomenon known as chemical hormesis. First, it argues that conceptual confusion contributes significantly to current disagreements about the status of chemical hormesis as a biological hypothesis. Second, it analyzes seven distinct concepts of chemical hormesis, arguing that none are completely satisfactory. Finally, it suggests three ramifications of this analysis for ongoing debates about the epistemological status of chemical hormesis. This serves as a case study supporting the value of philosophical methodologies (...) such as conceptual clarifica-tion for addressing contemporary scientific disputes, including policy-related scientific disputes that may be heavily in(integral)uenced by social and political factors. (shrink)

When does self-interest counsel cooperation? This question pertains both to the labile behaviors produced by rational deliberation and to the more instinctive and fixed behaviors produced by natural selection. In both cases, a standard starting point for the investigation is the one-shot prisoners' dilemma. In this game, each player has the option of producing one or the other of two behaviors. The pay-offs to the row player are as follows.

This three-volume series provides a critical examination of the history of theology in Scotland from the early middle ages to the close of the twentieth century. Volume I covers the period from the appearance of Christianity around the time of Columba to the era of Reformed Orthodoxy in the seventeenth century.

This three-volume series provides a critical examination of the history of theology in Scotland from the early middle ages to the close of the twentieth century. Volume II begins with the early Enlightenment and concludes in late Victorian Scotland.

This three-volume series provides a critical examination of the history of theology in Scotland from the early middle ages to the close of the twentieth century. In Volume Three, the 'long twentieth century' is examined with reference to changes in Scottish church life and society.

This article examines the ethnographic case study in education in the context of policy making with particular emphasis on the practice of research and policy making. The central claim of the article is that it is impossible to establish a transcendental epistemology of the case study on instrumental rationality. Instead it argues for the notion of situated judgement that needs to be made by practitioners in context, practitioners being both researchers and policy makers. In other words, questions about the level (...) of confidence or warrant that can be placed in different sorts of research evidence and findings cannot be answered independently of forming a view about the appropriateness of the policy culture that shapes political decision-making. The article draws a distinction between the general, which is internal to the data as construed by a particular discipline, and the universal, which is the result of embedded human deliberation. This applies to all research findings and not only to case study, although since case study has long had to defend itself against accusations of the lack of generality, it can be a useful starting point for the discussion. This article is not meant to be yet another defence of the case study research genre, although a summary of other defences is offered. Rather it focuses on how use of the case study points to the limits of epistemology as rationality and offers a view of epistemology as ethics. (shrink)

J. L. Schellenberg's Philosophy of Religion argues for a specific brand of sceptical religion that takes ‘Ultimism’ – the proposition that there is a metaphysically, axiologically, and soteriologically ultimate reality – to be the object to which the sceptical religionist should assent. In this article I shall argue that Ietsism – the proposition that there is merely something transcendental worth committing ourselves to religiously – is a preferable object of assent. This is for two primary reasons. First, Ietsism is far (...) more modest than Ultimism; Ietsism, in fact, is open to the truth of Ultimism, while the converse does not hold. Second, Ietsism can fulfil the same criteria that compel Schellenberg to argue for Ultimism. (shrink)

This article examines heterosexual fathers’ descriptions of conversations with their teen children about sexuality and their perceptions of their teen children’s sexual identities. We show that fathers construct their own identities as masculine and heterosexual in the context of these conversations and prefer that their children, especially sons, are heterosexual. Specifically, fathers feel accountable for their sons’ sexuality and model and craft heterosexuality for them, even as many encourage their sons to stay away from heterosexual relationships and sex until they (...) are older. Fathers are more accepting of homosexuality for their daughters yet question the authenticity of teen lesbian identity and do not recognize their daughters’ sexuality as agentic. They instead construct their daughters as sexually passive and vulnerable and position themselves as their daughters’ protectors. The findings illustrate the complexities of heteronormativity in a context of shifting, frequently contested gender and sexual landscapes. (shrink)

The revised edition of Subject to Ourselves, a lively and provocative book that was a leader on its topic in England, uses psychoanalytic theory as the basis for a fresh reassessment of the nature of modernity and postmodernism. Analyzing changing experiences of selfhood, desire, interpersonal relations, culture and globalization, the author develops a novel account of postmodernity that supplants current understandings of "fragmented selves." Subject to Ourselves includes a diverse set of case studies, including the power of fantasy in military (...) violence and war, the debate over sexual seduction in psychoanalysis, and the cultural uses of media and new information technologies. The book will be essential reading for students and professionals of social and political theory, psychoanalytic studies, psychology and cultural studies, as well as those with an interest in the modernity/postmodernity debate. Praise for the First Edition: 'This book not only fills an important gap in the literature, for it summarises a debate that is scattered across a decade of rather difficult texts, but also offers a resolution that is sensible and grounded in the best current thinking. It will be widely read by graduate students, faculty, and professionals in the humanities and social sciences.' Choice 'This is an informative and enjoyable book, which will be of use to students and academics...It is accessibly written and provides useful summaries of the different theories and debates in cultural and psychoanalytic theory. Recommended.' Radical Philosophy. (shrink)

The industrial revolution and the scientific revolution of the sixteenth and seventeenth centuries were two of the most important events in the whole of human history and the question of how these two relate to each other must therefore form one of the most vital of all inquiries in the history of science. As the industrial revolution began in England- and largely provincial England- the question of how scientific knowledge came to be disseminated to these regions forms a crucial part (...) of such an enquiry. Using Derby as a case study, this paper examines how Newtonian philosophy came to be spread, how and why science became a cultural activity as part of the Habermasean public sphere, and how scientific theory related to early industrial and technologicalventures in an English provincial town. The richness of Derby's scientific culture is revealed by the careers of John Whitehurst FRS, John Arden, Thomas Simpson FRS, Benjamin Parker and George Sorocold and the importance of science in the curriculum of the local Dissenting academy. (shrink)

Models provide scientists with knowledge about target systems. An important group of models are those that are called general. However, what exactly is meant by generality in this context is somewhat unclear. The aim of this paper is to draw out a distinction between two notions of generality that has implications for scientific practice. Some models are general in the sense that they apply to many systems in the world and have many particular targets. Another sense is captured by models (...) that are aimed at understanding the fundamental or underlying dynamics of a phenomenon, as opposed to how it manifests in each particular case. They have non-specific, i.e. generic targets. While both notions of generality and genericness are legitimate and correspond to different aspects of scientific practice, they must be distinguished. Failing to do so obscures the danger of overgeneralisation faced by general models and facilitates the illegitimate use of generic models as general models. This can lead to a reduction of the explanatory and predictive power of both. (shrink)

Patients trust physicians to prescribe based on their fiduciary duty to act in the best interests of their patients, and physicians prescribe based on confidence in research data and clinical guidelines. Recent reports erode confidence in evidence-based medicine. Through self-regulation and a willingness to change, the medical profession can assert its status as a profession distinct from outside influence, serving one interest: the healthcare of patients and the public.

For anyone with an interest in the philosophical teachings of Ch’an (Zen Buddhism), the Platform Sutra is arguably the classic source of philosophical as opposed to religious Ch’an. The text is exclusively concerned with expounding the nature of Ch’an and its key feature: enlightenment achieved by the mind alone or by pure understanding without the assistance of textual authority, religious devotion, charitable acts, meditative practices or monastic discipline. Yet, despite its centrality in Zen Buddhism, the book presents one account of (...) enlightenment that has received very little attention: the story of the General. It is commonly thought that emotions are to be repressed in order to attain enlightenment. The argument I would like to present is that one case of attaining enlightenment recounted in the Platform Sutra shows that one ought to take a very different attitude to desire and emotions than annihilation, tranquilization or repression. From the account of the General, it would appear that desires and emotions are not to be simply eradicated or repressed. Rather, they must first be expressed and then acknowledged as possessed before one can attain enlightenment. (shrink)